Day 1 :
Keynote Forum
Mahabaleshwar Hegde
Bharati Vidyapeeth University, India
Keynote: Distorted fatty acid metabolism and metabolic syndrome
Time : 08:30-09:30
Biography:
Mahableshwar Hegde, PhD in biochemistry, has over 30 years post garduate teaching experience, guiding M.Sc, M.Phil, PhD students at Pune University and for the last 20 years has passionately working for omega-3 nutritional security, by establishing a “Center for Innovation in Nutrition Health and Disease (CINHD)” and “Real World Nutrition Laboratory Foundation (RWNLF)” in Bharati Vidyapeeth (deemed to be)University Pune, to validate the innovative omega-3 enriched products throgh FLAX BIOVILLAGE” concept devloped by him. He has published extensively and edited a book “OMEGA 3 FATTY ACID” keys to nutritional health, published by Springer International.
Abstract:
Metabolic syndrome, is a collection of risk factors that increases the chances of developing excessive body fat, heart disease, stroke and diabetes and it is primarily the result of recent abrupt dietary life style changes, more particularly distorted fatty acid intake. Our prehistoric food consisted of 1:1 ratio of omega-6 to omega-3 fatty acid. But today our diet has skewed ratio of 20-40:1. Both linoleic acid omega-6 and alphalinolenic acid omega-3 fatty acids are essential fatty acids. Excessive omega-6 and paucity of omega-3 fatty acid is almost a global phenomenon. Th is has led to the dominance of infl ammatory pathway in modern man and is primarily responsible in phenomenal increase in incidences and severity of chronic degenerative diseases. Omega-3 nutritional security and lowering of intake omega-6 fatty acid, correcting the imbalance is urgent need of the day. Th erefore, our goal has been to bring back primary essential omega-3 fatty acid, alphalinolenic acid, into the food chain. Flax seed is the richest source of vegetarian, omega-3 fatty acid. We have developed technogies, to increase production and productivity of fl axseed; to extract omega-3 oil and soft gel capsules from fl axseed devoid of antinutrients; to stabilize omega-3 fatty acid in emulsion to fortify milk and milk products; omega-3 enriched poultry feed mix for the production omega-3 enriched egg and chicken meat; omega-3 fl our mix for bakery products etc. Our pioneering eff orts, through well researched and validated “FLAX BIO_VILLAGE” concept, aims at attaining omega-3 nutritional security and correct the omega-6: omega-3 imbalance, to eff ectively tackle metabolic syndrome.
Keynote Forum
Bandar Manawer Al Harbi
De Montfort University, UK
Keynote: Six weeks moderate-intensity combined aerobic and resistance exercise program could be antiinfl ammatory treatment and delaying the onset of diabetes for subjects at risk
Time : 09:30-10:30
Biography:
Bandar Manawer Al Harbi is working as Assistant Director of Pharmacy for Material Management at Prince Sultan Military Medical City. His current research is in diabetes at DMU University, UK. He is an Adjunct Clinical Assistant Professor at King Saud University, College of Pharmacy and Director of Pharmacy and Director of Central Sterile Supplies Department, PSMMC, Director of Medical Supplies and Purchasing, PSMMC. He is the Chairman of the fi rst International Sterilization Symposium, Instructor of Purchasing Material Management/CSSD course. He is the active Member of American Society of Health System Pharmacist (ASHP) and Saudi Commission for Health Care Specialties. He has participated in many conferences globally
Abstract:
Introduction & Aim: Pre-diabetes describes a condition whereby an individual’s level of blood glucose is above normal level, though not high enough to warrant them a T2D diagnosis. Th e condition is classifi ed into two categories, Impaired Glucose Tolerance (IGT) where blood glucose levels are above the normal 2 hours aft er glucose loading in the oral glucose tolerance test but not so high to warrant the classifi cation as diabetes. Th e other is Impaired Fasting Glucose (IFG) where blood glucose have risen to a fasting state but yet again, not so high to warrant the classifi cation as diabetes. Physical exercise improves BG homeostasis but the extent to which exercise is eff ective strategy as primary prevention mechanism for people whom at risk to develop diabetes is not fully understood. Th e study aims to examine the eff ects of 6-weekes moderate-intensity combined aerobic and resistance exercise program in preventing or delaying the onset of diabetes for subjects at risk compared to sedentary non-diabetic individuals. Method: 20 subjects of a sedentary lifestyle, diagnosed with either pre-diabetes or at risk to developed T2D (PRE-D) and 5 subjects were sedentary healthy individuals (ND) met the inclusion criteria. Both PRE-D and ND have been asked to complete 6-weeks of moderate-intensity combined aerobic and resistance exercise for 60 minutes on two days/week. Each exercise session consists of a combined exercise protocol of 30 minutes of resistance exercise (3 sets of 10 repetitions) followed by 20 minutes cycling. Th e primary outcome is to concentrate on metabolic results, such as improved HbA1c, blood pressure, heart rate, 1-repition max, lipid profi le (reduction in total cholesterol, low density lipoproteins, triglycerides or increase high density lipoproteins) and improvements in insulin sensitivity determined by responses to oral glucose tolerance tests on independent days. Result: Th ere were signifi cant reduction (p=0.00) on the HbA1c aft er applying of 6 weeks’ combination exercise intervention in both groups comparing to baseline. OGTT indicated signifi cant diff erences between pre-exercise and post 12th exercise session in both groups with p=0.01. BG concentrations.
Keynote Forum
Najmul Islam
Aligarh Muslim University, India
Keynote: Allicin from garlic having beneficial effects in combating diseases
Time : 10:45-11:15
Biography:
Najmul Islam is currently working as a Professor in Biochemistry, Faculty of Medicine, Aligarh Muslim University, India. He was the Former Head of the Department of Biochemistry. He has worked for four years in the Division of Infectious Diseases and Department of Rheumatology, Case Eastern Reserve University, Cleveland, Ohio, USA. He was Joint Secretary in 2012-13, Vice President, 2014 and President, 2015 of Indian Academy of Biomedical Sciences, Lucknow. He has published more than 70 papers/articles in reputed journals and has been serving as an Editorial Board Member of repute.
Abstract:
Introduction & Aim: Th e relationship between Reactive Oxygen Species (ROS) and various diseases like metabolic cardiac disorders, osteoporosis, tuberculosis and cancer and are well documented. Th e present study involves the employment of a natural compound namely allicin from garlic having anti-oxidant and anti-infl ammatory properties with proven health benefi ts. Our preliminary observations appear to possibly provide some scientifi c input that may be useful in the management of Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer. Method: Peripheral Blood Mononuclear Cells (PBMC’s) were isolated by density gradient method from blood of patients with Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer (n=20 each) and were employed in culture studies with and without of varying does of allicin (0-500 ng/ml). Th e 24 hr cultures were probed for CK, sTNF-alpha, sRANKL levels as well as for Glutathione Peroxidase (GPx) activity. Result: Cells were collected aft er 24 hours with and without allicin (0-500 ng/ml; n=20 each). An appreciably suppressed GPx activity was recorded in cell cultures of patient’s with IHD, osteoporosis, tuberculosis and cancer when compared to samples of healthy controls where the GPx data refl ects upon the compromised defense system in patients with Ischemic Heart Disease (IHD). On the contrary, treatment or co-culturing with varying doses of allicin (0-500 ng/ml) exhibited a remarkable degree of amelioration in GPx activity in cells of all the above four types of diseased patients. Next, the ELISA data showed that the 24 hr culture supernatants of untreated patients cells were having augmented expressions of sTNF-alpha, which upon co-culturing with 500 ng/ml of allicin resulted in an appreciable degree of downregulation/suppression in the expressions of sTNF-alpha in cells of all the above four types of diseased patients. Cultures from all patient types exhibited a dose dependent suppression with allicin. Similarly, in IHD patients, in comparison to untreated controls, a dose dependent decrease in CK levels were observed in cultures receiving allicin (0-500 ng/ml; n=10). Also, in cell cultures from osteoporosis patients, allicin (0-500 ng/ ml), showed an appreciable degree of downregulation in sRANKL. Conclusion: Th e encouraging preliminary data suggested that in-depth studies are required at the molecular level, which in turn, may provide information for possibly employing allicin as potential adjunct in the management of Ischemic Heart Disease (IHD), osteoporosis, tuberculosis and cancer. repute.
Keynote Forum
Nicolas Wiernsperger
Association REMEDES, France
Keynote: Anti-obesity potential of aged garlic extract: Overview
Time : 14:00-15:00
Biography:
Nicolas Wiernsperger is a Physiologist and has completed his PhD in Neurophysiology from University Basel, Switzerland. He has worked as the Head of Department of Brain Microcirculation at Novartis and also he was the Head of International Pharmacological Development at Lipha/Merck KgA in Lyon. He was also Head of a Private/ Public Research Unit on Diabetic Micro vascular Complications at Lyon University. He has been an Author/Co-author of about 150 publications and 2 scientifi c books. He has also worked as a Visiting Professor at several universities. He is presently a Private Consultant for Pathophysiological and Pharmacological aspects of cardio metabolic diseases.
Abstract:
Obesity is a hallmark of pre-diabetes with a conversion rate of close to 10%. However, recent large-scale clinical observations tell us that non-diabetic obesity (metabolic syndrome) is as dangerous as established diabetes for macro angiopathy. Obesity is becoming a huge worldwide health problem and actual lifestyle measures are of limited effi cacy, in addition to be diffi cult to sustain. Th erefore, complementary dietary measures are highly suitable. Among these, garlic and more particularly aged (black) garlic, is of particular potential interest based on its pharmacological properties which target most of the individual parameters causally involved in obesity development. Although a lot has still to be learned and precised about ideal composition and dosage for humans, animal research shows promising benefi cial eff ects. A recent trial with concentrated aged garlic extract has demonstrated impressive loss of weight over short treatment duration in high fat/high sucrose chronic fed rats. Several mechanisms, including central eff ects in hypothalamus, have emerged.
- Diabetes Mellitus | Biochemistry & Metabolism | Diet for Diabetes | Cardio-Metabolic Disorder | Obesity and Weight Management
Location: Carlton Palace Hotel, Dubai
Chair
James Joseph
God’s Own Food Solution Pvt Ltd., India
Co-Chair
Ajmila Islam
American University in Dubai, UAE
Session Introduction
Samih Abed Odhaib
American Association of Clinical Endocrinologist, Iraq
Title: He lost 18 kilograms and his diabetes
Biography:
Abstract:
The T2DM in adulthood is strongly related to weight gain and excessive accumulation of pancreatic and hepatic fat. It is very uncommon to have remission without bariatric surgery. Acute negative energy balance can reverse the twin defects of beta cell failure and insulin resistance alone with diet restriction to around 700 kcal that results in decreased pancreatic and liver triacylglycerol stores. Weight loss of at least 10-15 kg has been shown to achieve euglycemia in people with shortduration T2DM for at least 12 months. A 48-year old diabetic male presented to Faiha Specialized Diabetes, Endocrine and Metabolism Center two years ago with very poorly controlled T2DM that was diagnosed more than 3 years ago, along with severe hypertension and marked dyslipidemia. He underwent complete remission of his diabetes aft er losing 18 kg of his original weight (58 kg), with a very good euglycemia measures, on no treatment at all for the last two years. Th e eff ect that extends to make him have normal blood pressure and normal lipid profi le, with decreased cardiovascular risk from 26% to be less than 1%.
Biography:
Archana Arora is a Registered Dietitian and has been practicing for more than 20 years in the fitness, healthcare, wellness and catering industries. She has completed her Masters in Food and Nutrition in 1995 followed by an internship at the All India Institute of Medical Sciences, New Delhi. Currently, she is working as a Senior Dietitian and Health Coach at NU Foods, Dubai.
Abstract:
Way of life is central to human wellbeing, from what we eat, how much we move, what we think, what chemicals we are exposed to, how we deal with our emotions and the quality of sleep and the list goes on. Epigenetics (a change in our genetic activity without changing our genetic code) shows that genetics is only 30% of the health equation, with lifestyle choices being 70%. But do we realize it is the wrong lifestyle choices we make, that prepare our body for disease and lead to death. Self-analyzation, willingness to change, continuous wellness journey with trustworthy professional, self-effi cacy evolution (people’s belief that they have the ability to perform particular behaviors) and perseverance can be the most obvious drivers of signifi cant health evolution in your life. With practice, we can enhance our wellbeing and achieve a state of balance and contentment. Lifestyle choices that we make are the basis of our well-being and enhanced quality of life.
Raghda A Hamid
The University of Jordan, Jordan
Title: Role of diabetic nurse educator in screening, prevention, and management of diabetes
Biography:
Ragdah A Hamid has completed her Bachelor’s degree in Nursing from The University of Jordan and her Post Graduation Diploma in Diabetes Primary Care from St. Geroge University School of Medicine. She is the Diabetes Nurse Educator in King Saud Medical City, Riyadh.
Abstract:
Introduction: The Diabetes Nurse Educator (CDE) role in King Saud Medical City is a new approach to improving the quality of staff competencies in the care of patients with diabetes. The Diabetes Nurse Educator is an advanced nursing clinician with a focused expert practice area who works to improve the care at the bedside by combining roles as clinician, consultant, researcher, educator, and manager. The Diabetes Nurse Educator has specific responsibilities in serving as an expert in the specialty, ensuring the incorporation of evidence-based practices, promoting research, evaluating the staff nurses’ practice, providing continuous learning opportunities, and promoting critical thinking and problem-solving.
Location/Setting: King Saud Medical City-Riyadh, Endocrinology Department – Diabetes Division Outpatient Clinic and In-patient Units- General Hospital Objective: The goal of implementing the Diabetes Nurse Educator role at King Saud Medical City (KSMC) was to improve the quality, safety, effectiveness, and efficiency of staff nurses caring for patients with diabetes.
Activities: The Diabetes Nurse Educator activities include: The Development and Implementation of Educational Programs for Staff Nurses, Participating in Staff General Nursing Orientation Program (GNO),Organizing Hospital Continuous Nurse Education (HCNE) and Unit Continuous Nurse Education (UCNE) activities in clinical areas Developing Multidisciplinary Educational Programs through the year with other Health Care Professionals, Leading Nursing Grand Rounds and In-service Education, Provide Clinical Resource and Consultation to Staff Nurses in Collaboration with the Endocrine Team, Developing and Implementing Written Protocols and Order Sets in Coordination with Endocrine Team, Working within the community to promote health care including education and training for Community to Support Workers
Conclusion: The CDE plays an integral role in the prevention, diagnosis and adequate management of diabetes. This specialist role can increase skills, knowledge, and confidence, as well as support and empower staff nurses who deal with diabetic patients and help to reduce the chances of developing further complications of the disease.
Maha Mohammed Arnous
Security Forced Hospital, Saudi Arabia
Title: Association of atrial fibrillation with diabetic nephropathy: A meta-analysis
Biography:
Maha Mohammed Arnous has completed his MD degree from School of Medicine in King Fahad Medical City in Riyadh, Saudi Arabia. She is the Senior Resident of Community and Family Medicine at Security Forced Hospital. She is very active in clinical research of diabetes care and prevention.
Abstract:
Background: Many studies have provided evidence for an increased risk of atrial fibrillation among diabetic patients as compared to the non-diabetic population. It is also well known that diabetes predisposes a person to an increased risk of diabetic nephropathy. A few reviews and studies have hinted towards an increased risk of atrial fibrillation among diabetic nephropathy patients.
Aim: To conduct a meta-analysis to explore if there is an association between diabetic nephropathy and atrial fibrillation.
Methods: The available literature was searched for relevant studies from the period of January 1995 to October 2018. The following quality assessment criterion were considered for study shortlisting: Clearly defined comparison groups, same outcome measured in both comparison groups, known confounders addressed and a sufficiently long and complete (more than 80%) follow-up of patients. Two independent reviewers searched the databases, formed their search strategies and finalized the studies. Data was analyzed to obtain a summary odds ratio along with a forest plot by Cochrane’s RevMan 5.3.
Results: Only four studies were found to meet the inclusion criterion for this meta-analysis (total number of study participants: 307330, diabetic nephropathy patients: 22855). Of these, two were retrospective cross-sectional studies, one was a prospective cohort study and one was a case-control study. Three studies had provided the odds ratio as the measure of effect (two retrospective cross-sectional studies and one case-control study), with the one cohort study reporting the hazards ratio as the measure of effect. Therefore, the meta-analysis was done excluding the cohort study. The summary odds ratio in the present study was 1.32 (0.80-2.18), which was not statistically significant. Due to large heterogeneity among the included studies and their small sample sizes, it was found that the summary estimate shifted towards the null value.
Conclusion: The present meta-analysis found no significant association between atrial fibrillation and diabetic nephropathy. However more studies with large sample sizes are required to strengthen the evidence for an association.
Sultan Al Dalbhi
Prince Sultan Military Medical City, Saudi Arabia
Title: A dose response analysis of dual Renin Angiotensin Aldosterone System (RAAS) blockade among diabetic nephropathy patients with albuminuria and proteinuria: A meta-analysis
Biography:
Abstract:
Bart A Van Wagensveld & Karla El Barmaki
Quro Obesity Center, UAE
Title: Obesity and weight management
Biography:
Abstract:
According to WHO, obesity is defined as an abnormal or excessive fat accumulation that presents a risk to health. It is measured based on the BMI (BMI (kg/m2) =Weight (kg) ÷ Height (m2)) Based on the BMI value people are classified as underweight (<18.5), Normal (18.5-24.9), overweight (25-29.9), obesity (30-39.9) and morbid obesity (40+). The study shows that the main causes of obesity were peoples energy intake was high compared to expenditure which leads to increasing obesity levels. Worldwide obesity has more than tripled since 1975. In 2016, more than 1.9 billion (39%) adults (≥ 18 years) were overweight (39% of men and 40% of women). Of these, over 650 million (13%) were obese (11% of men and 15% of women). Most of the world’s population lives in countries where overweight and obesity kills more people than underweight. 41 million children under the age of 5 were overweight or obese in 2016. In order to reduce the rate of morbid obesity, bariatric surgery is the only effective treatment with long-lasting results. Bariatric surgery leads to a reduction in mortality rates after 5Y, which translates to a decrease in the relative risk of death by 89%. It is also known that obesity is a major risk factor for developing T2DM, with 86% of T2DM patients were either overweight or obese in the UK from this study. Thus, significantly higher diabetes remission rates were reported for gastric bypass (p<0.001) and biliopancreatic diversion (p<0.001) compared to medical therapy.
Mohsina Hyder K
JSS Academy of Higher Education and Research, India
Title: Knowledge, attitude and practice among prediabetes participated in prediabetes education program
Biography:
Abstract:
Lailan Safina Nasution
University of Indonesia, Indonesia
Title: The adipocyte response to autophagy in adult rat groups receiving different nutritional treatments during childhood
Biography:
Abstract:
- Advanced Treatments for Diabetes | Biochemistry & Metabolism | Obesity Health Effects | Nutrition and Health | Diabetes Nutrition | Control of Obesity
Location: Carlton Palace Hotel, Dubai
Chair
Moinuddin
Aligarh Muslim University, India
Co-Chair
Dana Al-Hamwi
Dr. Dana Diet Center, UAE
Session Introduction
James Joseph
God's Own Food Solution Pvt Ltd., India
Title: New evidence to prove green jackfruit can reduce lifestyle diseases and demand for diabetic medication
Biography:
James Joseph has completed his Masters in Engineering Business Management from University of Warwick, UK and has a Degree in Mechanical Engineering from the College of Engineering, Thiruvananthapuram.
Abstract:
Ajmila Islam
American University in Dubai, UAE
Title: Whole grains, fruits and vegetables: Do they help in weight management
Biography:
Abstract:
Tigist W Leulseged
St. Paul Hospital Millennium Medical College, Ethiopia
Title: Time to optimal glycaemic control and prognostic factors among Type 2 diabetes mellitus patients in public teaching hospitals in Addis Ababa, Ethiopia
Biography:
Abstract:
Background: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. Poorly managed diabetes leads to serious complications and early death. The prevalence of diabetes has been increasing over the past few decades. Ethiopia is one of African countries with the highest number of people living with diabetes. Studies conducted in Ethiopia and other countries mainly focused on level of glycemic control at one point in time. Studies targeting the time that a patient stayed in a poor glycemic level are lacking.
Objective: To estimate time to fi rst optimal glycemic control and to identify prognostic factors among Type-2 Diabetes Mellitus (T2DM) patients in public teaching hospitals in Addis Ababa, Ethiopia.
Methods: A hospital based retrospective chart review study was conducted from April to July 2018 at diabetes clinic of Addis Ababa’s public teaching hospitals among randomly selected sample of 685 charts of T2DM patients who were on follow up from January 1, 2013 to June 30, 2017. Data was collected using pretested data abstraction tool. Data was checked, coded and entered to Epi-Info V.7.2.1.0 and exported to SPSS V.23.0 and STATA V.14.1 for analysis. Descriptive statistics is presented with frequency tables, KaplanMeier plots and median survival times. Association was done using Log-rank test and Cox proportional hazard survival model, where hazard ratio, P-value and 95% CI for hazard ratio were used for testing signifi cance and interpretation of results.
Results: Median time to fi rst optimal glycemic control among the study population was 9.5 months. Th e major factors that aff ect it are age group (HR=0.635, 95% CI: 0.486-0.831 for 50-59 years, HR=0.558, 95% CI: 0.403-0.771 for 60-69 years and HR=0.495, 95% CI: 0.310-0.790 for ≥70 years), diabetes neuropathy (HR=0.502, 95% CI: 0.375-0.672), more than one complication (HR=0.381, 95% CI: 0.177-0.816), hypertension (HR=0.611, 95% CI: 0.486-0.769), dyslipidemia (HR=0.609, 95% CI: 0.450-0.824), cardiovascular disease (HR=0.670, 95% CI: 0.458-0.979) and hospital patient treated at (HR=1.273, 95% CI: 1.052-1.541).
Conclusion: Median time to first optimal glycemic control among T2DM patients is longer than expected which might imply that patients are being exposed to more risk of complication and death.
Vani Pulijala
Astra Healthcare Private Limited, India
Title: Make tea as your new medicine to prevent the epidemic of lifestyle diseases
