Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd World Congress on Nutrition and Obesity Prevention Dubai, UAE.

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Scientific Program Day 1
Scientific Program Day 2

Day 2 :

Keynote Forum

Moinuddin

Aligarh Muslim University, India

Keynote: Glycoxidative modification of proteins in diabetes results in generation of neo-antigenic epitopes
Conference Series Nutrition Meet 2019 International Conference Keynote Speaker Moinuddin photo
Biography:

Moinuddin has completed his MPhil and PhD in Biochemistry from the Faculty of Medicine of the Aligarh Muslim University, India. His research interest includes nucleic acid immunology, autoimmunity and free radical biology. He has published over 90 papers in reputed international journals, Seminars In Cancer Biology, FEBS Letters, ABB, BBRC, Rheumatology, PLoS One, IUBMB Life, etc. He is the recipient of Commonwealth Academic Fellowship to work in UK. He is a Life Member of Society for Free Radical Research (SFRR) and Indian Academy of Biomedical Sciences (IABS).

Abstract:

Structural rearrangements and condensations of proteins under glycoxidative stress have been implicated in various pathological disorders. Novel immunological epitopes upon glycoxidatively modified proteins have been discovered and multi-specific natural antibodies against them have been identified. In this study, we have probed the glycoxidation of Human Serum Albumin (HSA) and human IgG in diabetes type-2. Glycoxidation was found to perturb the structural integrity of HSA and IgG. It affected their aromatic micro-environment and caused the generation of Advanced Glycation End products (AGEs) and aggregate adducts. Generation of N-epsilon-Carboxy Methyl Lysine (CML) was observed under HPLC and LCMS studies. The modified proteins showed altered secondary and tertiary structure that would also affect their function. Glycoxidation caused disordered or amorphous type aggregation in the modified proteins, as confirmed by electron microscopy. It enhanced carbonyl content and reduced the free lysine and arginine content. Modified HSA and IgG presented novel antigenic determinants that lead to an aggressive immune response in the immunized rabbits as was evaluated by ELISA studies. The antibodies had high affinity towards the immunogens. Auto-antibodies derived from T2DM patients exhibited strong affinity towards the modified HSA and IgG in comparison to the respective unmodified proteins. Specificity of serum antibodies from T2DM patients was further confirmed by competitive-inhibition ELISA and gel retardation assays. The study shows that the neo-antigenic determinants on glycoxidatively modified proteins generate specific immune response in diabetes type-2, which may possibly lead to the biomarker development for the disease.
 

Keynote Forum

Bulbin Jose

Latifa Hospital, UAE

Keynote: Nutrition management in bariatric surgery
Conference Series Nutrition Meet 2019 International Conference Keynote Speaker Bulbin Jose photo
Biography:

Bulbin Jose is a Registered Dietitian and is currently pursuing her PhD in Food Science and Nutrition from Bharathiar University Coimbatore, India. She has completed her MPhil degree in Food Science and Nutrition from Mother Theresa Women’s University, Kodaikkanal India in 2008. She has pursued her Master Degree in Food Science and Nutrition from Bharathiar University in 2003 and Bachelor Degree in Clinical Nutrition and Dietetics from M.G University, Kottayam, Kerala, India. She has completed her Food Safety Certifi cation course from IGNOU, New Delhi India and she cleared UGC-NET Exam in 2010. She has 15 years working experience as a clinical dietitian and lecturer in various multi super specialty hospitals in various countries. Currently she is working as Senior Clinical Dietitian in Dubai Health Authority. She has published several research papers in scientifi c peer reviewed international journals and she is speaker for various conferences.
 

Abstract:

Bariatric surgery is the most effective treatment method to help people with morbid obesity to lose weight and manage their health and weight. Bariatric surgeries can be divided into three categories such as restrictive procedures, malabsorptive procedures and combination (restrictive and malabsorption) procedures. Generally, patients undergoing restrictive procedures have the least risk for long-term diet-related complications, whereas patients undergoing malabsorptive procedures have the highest risk. In many patients, the benefits of weight loss, such as decreased blood glucose, lipids and blood pressure and increased mobility, will outweigh the risks of surgical complications. Most diet-related surgical complications can be prevented by following a strict eating behavior guidelines and supplement prescriptions. Eating behavior guidelines include restricting portion sizes, chewing foods slowly and completely, eating and drinking separately and avoiding foods that are poorly tolerated. Supplement prescriptions vary among practitioners and usually involve at least a multivitamin with minerals. Some practitioners may add other supplements only as needed for diagnosed deficiencies; others may prescribe additional prophylactic supplements. The most common nutrient deficiencies are deficiency of iron, foliate and vitamin B12. Fat-soluble vitamins such as vitamin A, D, E and K have been reported in patients with malabsorption procedures and Thiamine deficiency is very common among patients with inadequate food intake and/or nausea and vomiting. The diet after bariatric surgery is different from all other diets. So plan the menu based on the nutrient requirements and adhere to that to lead a healthy post bariatric surgery life. Frequent monitoring of nutrition status for all patients undergone bariatric surgeries can be helpful in preventing severe clinical deficiencies.

Keynote Forum

Khurshid Alam

Aligarh Muslim University, India

Keynote: Diabetic animals injected with human IgG-methylglyoxal-glucose complex elicit antibodies and shows increase in biochemical markers of rheumatoid arthritis: Correlation with data on diabetic patients of varying age and disease duration
Conference Series Nutrition Meet 2019 International Conference Keynote Speaker Khurshid Alam photo
Biography:

Khurshid Alam completed his PhD in 1993 from Aligarh Muslim University College of Medicine. He became Faculty in the same year and teaching to undergraduate, postgraduate and doctoral students since then. He has already supervised 10 PhD and 05 MD and successfully operated 06 research projects. He has published more than 80 papers in journals of international repute.
 

Abstract:

Background & Aim: Naturally occurring proteins are signifi cantly more immunogenic than oligosaccharides and polysaccharides. The study of modified-human IgG antigenicity is of particular interest due to the involvement of anti-IgG antibodies in the immunopathology of Rheumatoid Arthritis (RA). Human IgG show immunological behavior in its native conformation but glycation by ribose / deoxyribose / glucose / fructose / glyoxal / methylglyoxal etc. causes structural changes in the IgG and immunogenicity enhancement. In poorly controlled diabetes mellitus and in hyperglycaemia methylglyoxal formation is accelerated. In that scenario IgG being rich in lysine can be a soft  target of heavy glycation by methylglyoxal/glucose duo. The glycation may progress to Amadori stage culminate into Advanced Glycation End products (AGE) and may further result in aggregate formation. The study aims to evaluate whether diabetic animals injected with IgG-methylglyoxal-glucose complex would elicit antibodies against the complex and also show increase in biochemical markers typical of RA. The sera of diabetes mellitus patients of diff erent age and disease duration will also be analyzed for auto antibodies against IgG-methylglyoxalglucose complex and markers of RA.
 
Method: Experimental diabetes would be induced into rabbits by alloxan. Next, the diabetic rabbits will be injected weekly for seven weeks with IgG-methyglyoxal-glucose complex. Th e induction of antibodies and its specifi city would be evaluated by direct binding and specifi city enzyme immunoassay, respectively. Rheumatoid Factor (RF), TNF-α, IL-1 and 6 and CRP level will be estimated in the rabbit sera as well as in the sera diabetic patients of different age and disease duration.
 
Result: Diabetic animals challenged with IgG-methylglyoxal-glucose complex induced high titer antibodies having excellent specifi city towards the immunogens. Th e level of RF, TNF-α, IL-1 and 6 and CRP in immunogens injected diabetic sera was above respective cut-off  values and signifi cantly more as compared to values in the sera of healthy or diabetic rabbits. Furthermore, auto antibodies in sera of diabetic patients showed enhanced binding with IgG-methylglyoxal-glucose complex. In a signifi cant number of cases, but not all that were included in this study, there was direct correlation between level of serum autoantibodies and age of the patients and duration of diabetes mellitus. Another important observation made during the study was that the sera which showed high level of autoantibodies also showed significantly high level of RF, TNF-α, IL-1 and 6 and CRP.
 
Conclusion: Th e results obtained so far suggests that IgG-methylglyoxal-glucose complex may have a role in the development of arthritis-like features in long term patients of diabetes mellitus. More biochemical parameters need to be analyzed in diabetic sera of immunized animals as well diabetes mellitus patients, including study of biochemical in joint fluid of healthy and immunized rabbits.
 

Keynote Forum

Mohmmad Kamil

Zayed Complex for Herbal Research & Trad.Medicine, UAE

Keynote: Plants with special reference to flavanoids and their role in nutrition and obesity prevention
Conference Series Nutrition Meet 2019 International Conference Keynote Speaker Mohmmad Kamil photo
Biography:

Mohammad Kamil is a Fellow of Royal Society of Chemistry London, Head TCAM Research, Zayed Complex for Herbal Research and Traditional Medicine, Healthcare Licensing and Medical Education Division, Department of Health, Abu Dhabi, UAE. He was the recipient of Common Wealth Award-London, Convention Award of Chemical Society-India; Fellowship from Association of Common Wealth Universities-London, Global award on Unani Medicine. He has worked as Incharge of Drug laboratory, MoH India, Professor Jamia Hamdard University. He has more than 360 papers and abstracts in reputed journals and conferences.

Abstract:

The plant kingdom offers a rich source of structural biodiversity in the form of a variety of natural products. As we know natural products continue to play an important role especially in and food and pharmaceutical industries. Besides medicament, plants have always been a common source of food and nutrition either as such or as dietary supplements. The unique nutrient richness of every whole, natural food can be show cased in a variety of ways. But there is no better way to highlight the unique nutrient richness of foods than to focus on their flavonoid content. Flavonoid, one of the largest nutrient families known to scientists, covers a large group of naturally occurring, low molecular phenolic compounds found practically in all parts of the plant, include over 6,000 already-identified family members. A large number of novel flavonoids and bi flavonoids have been isolated from medicinal plants. Some of the best-known flavonoids include quercetin, kaempferol, catechins and anthocyanidins. Obesity is the most prevalent nutritional disease and a growing public health problem worldwide. In this talk the anti-obesity potential of diverse plants such as Aloe vera, Camellia sinensis, Hibiscus sabdariffa, Hypericum perforatum, Phaseolus vulgaris, Capsicum annuum, Rosmarinus officinalis, Citrus limon, Punica granatum and some other common plants will be discussed. Researchers consider the potential of these plants as natural alternative treatments of some metabolic alterations associated with obesity. Market dietary supplements for obesity frequently contain undeclared/ hidden active ingredients that could be harmful to public health, the laboratory experience on this intensional adulteration shows that Plants play a untrivial role in public Health which is free from Adulteration contamination when compared with modern medicines. Hence plants with special reference to flavonoids helps and prevents us from mutation especially in obesity prevention.

  • Diabetes Mellitus | Biochemistry & Metabolism | Diet for Diabetes | Cardio-Metabolic Disorder | Obesity and Weight Management
Location: Carlton Palace Hotel, Dubai
Speaker

Chair

James Joseph

God’s Own Food Solution Pvt Ltd., India

Speaker

Co-Chair

Ajmila Islam

American University in Dubai, UAE

Session Introduction

Samih Abed Odhaib

American Association of Clinical Endocrinologist, Iraq

Title: He lost 18 kilograms and his diabetes
Speaker
Biography:

Samih Abed Odhaib has completed his PhD from Nahrain Medical School. He is a Fellow of Iraqi Board of Medical Specialization (Internal Medicine) FIBMS, Member of American College of Physician (ACP), Member of American Association of Clinical Endocrinologist (AACE).
 

 

Abstract:

The T2DM in adulthood is strongly related to weight gain and excessive accumulation of pancreatic and hepatic fat. It is very uncommon to have remission without bariatric surgery. Acute negative energy balance can reverse the twin defects of beta cell failure and insulin resistance alone with diet restriction to around 700 kcal that results in decreased pancreatic and liver triacylglycerol stores. Weight loss of at least 10-15 kg has been shown to achieve euglycemia in people with shortduration T2DM for at least 12 months. A 48-year old diabetic male presented to Faiha Specialized Diabetes, Endocrine and Metabolism Center two years ago with very poorly controlled T2DM that was diagnosed more than 3 years ago, along with severe hypertension and marked dyslipidemia. He underwent complete remission of his diabetes aft er losing 18 kg of his original weight (58 kg), with a very good euglycemia measures, on no treatment at all for the last two years. Th e eff ect that extends to make him have normal blood pressure and normal lipid profi le, with decreased cardiovascular risk from 26% to be less than 1%.

Archana Arora

NU Foods, UAE

Title: Well being is truly a matter of choice
Speaker
Biography:

Archana Arora is a Registered Dietitian and has been practicing for more than 20 years in the fitness, healthcare, wellness and catering industries. She has completed her Masters in Food and Nutrition in 1995 followed by an internship at the All India Institute of Medical Sciences, New Delhi. Currently, she is working as a Senior Dietitian and Health Coach at NU Foods, Dubai.

Abstract:

Way of life is central to human wellbeing, from what we eat, how much we move, what we think, what chemicals we are exposed to, how we deal with our emotions and the quality of sleep and the list goes on. Epigenetics (a change in our genetic activity without changing our genetic code) shows that genetics is only 30% of the health equation, with lifestyle choices being 70%. But do we realize it is the wrong lifestyle choices we make, that prepare our body for disease and lead to death. Self-analyzation, willingness to change, continuous wellness journey with trustworthy professional, self-effi cacy evolution (people’s belief that they have the ability to perform particular behaviors) and perseverance can be the most obvious drivers of signifi cant health evolution in your life. With practice, we can enhance our wellbeing and achieve a state of balance and contentment. Lifestyle choices that we make are the basis of our well-being and enhanced quality of life.

Raghda A Hamid

The University of Jordan, Jordan

Title: Role of diabetic nurse educator in screening, prevention, and management of diabetes
Speaker
Biography:

Ragdah A Hamid has completed her Bachelor’s degree in Nursing from The University of Jordan and her Post Graduation Diploma in Diabetes Primary Care from St. Geroge University School of Medicine. She is the Diabetes Nurse Educator in King Saud Medical City, Riyadh.

Abstract:

Introduction: The Diabetes Nurse Educator (CDE) role in King Saud Medical City is a new approach to improving the quality of staff competencies in the care of patients with diabetes. The Diabetes Nurse Educator is an advanced nursing clinician with a focused expert practice area who works to improve the care at the bedside by combining roles as clinician, consultant, researcher, educator, and manager. The Diabetes Nurse Educator has specific responsibilities in serving as an expert in the specialty, ensuring the incorporation of evidence-based practices, promoting research, evaluating the staff nurses’ practice, providing continuous learning opportunities, and promoting critical thinking and problem-solving.

Location/Setting: King Saud Medical City-Riyadh, Endocrinology Department – Diabetes Division Outpatient Clinic and In-patient Units- General Hospital Objective: The goal of implementing the Diabetes Nurse Educator role at King Saud Medical City (KSMC) was to improve the quality, safety, effectiveness, and efficiency of staff nurses caring for patients with diabetes.

Activities: The Diabetes Nurse Educator activities include: The Development and Implementation of Educational Programs for Staff Nurses, Participating in Staff General Nursing Orientation Program (GNO),Organizing Hospital Continuous Nurse Education (HCNE) and Unit Continuous Nurse Education (UCNE) activities in clinical areas Developing Multidisciplinary Educational Programs through the year with other Health Care Professionals, Leading Nursing Grand Rounds and In-service Education, Provide Clinical Resource and Consultation to Staff Nurses in Collaboration with the Endocrine Team, Developing and Implementing Written Protocols and Order Sets in Coordination with Endocrine Team, Working within the community to promote health care including education and training for Community to Support Workers

Conclusion: The CDE plays an integral role in the prevention, diagnosis and adequate management of diabetes. This specialist role can increase skills, knowledge, and confidence, as well as support and empower staff nurses who deal with diabetic patients and help to reduce the chances of developing further complications of the disease.

Maha Mohammed Arnous

Security Forced Hospital, Saudi Arabia

Title: Association of atrial fibrillation with diabetic nephropathy: A meta-analysis
Speaker
Biography:

Maha Mohammed Arnous has completed his MD degree from School of Medicine in King Fahad Medical City in Riyadh, Saudi Arabia. She is the Senior Resident of Community and Family Medicine at Security Forced Hospital. She is very active in clinical research of diabetes care and prevention.

Abstract:

Background: Many studies have provided evidence for an increased risk of atrial fibrillation among diabetic patients as compared to the non-diabetic population. It is also well known that diabetes predisposes a person to an increased risk of diabetic nephropathy. A few reviews and studies have hinted towards an increased risk of atrial fibrillation among diabetic nephropathy patients.

Aim: To conduct a meta-analysis to explore if there is an association between diabetic nephropathy and atrial fibrillation.

Methods: The available literature was searched for relevant studies from the period of January 1995 to October 2018. The following quality assessment criterion were considered for study shortlisting: Clearly defined comparison groups, same outcome measured in both comparison groups, known confounders addressed and a sufficiently long and complete (more than 80%) follow-up of patients. Two independent reviewers searched the databases, formed their search strategies and finalized the studies. Data was analyzed to obtain a summary odds ratio along with a forest plot by Cochrane’s RevMan 5.3.

Results: Only four studies were found to meet the inclusion criterion for this meta-analysis (total number of study participants: 307330, diabetic nephropathy patients: 22855). Of these, two were retrospective cross-sectional studies, one was a prospective cohort study and one was a case-control study. Three studies had provided the odds ratio as the measure of effect (two retrospective cross-sectional studies and one case-control study), with the one cohort study reporting the hazards ratio as the measure of effect. Therefore, the meta-analysis was done excluding the cohort study. The summary odds ratio in the present study was 1.32 (0.80-2.18), which was not statistically significant. Due to large heterogeneity among the included studies and their small sample sizes, it was found that the summary estimate shifted towards the null value.

Conclusion: The present meta-analysis found no significant association between atrial fibrillation and diabetic nephropathy. However more studies with large sample sizes are required to strengthen the evidence for an association.

Sultan Al Dalbhi

Prince Sultan Military Medical City, Saudi Arabia

Title: A dose response analysis of dual Renin Angiotensin Aldosterone System (RAAS) blockade among diabetic nephropathy patients with albuminuria and proteinuria: A meta-analysis
Speaker
Biography:

Sultan Al Dalbhi has completed his Clinical Fellowship in Nephrology and Clinical Research Associate degree from School of Medicine in McMaster University and University of Toronto. He is currently a Consultant Nephrologist at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. He is very active as Clinical Researcher in diabetic nephropathy care and prevention.
 

Abstract:

Treatment with Renin Angiotensin Aldosterone System (RAAS) blockade including Angiotensin-Converting Enzyme inhibitors (ACEis) and Angiotensin II Receptor Blockers (ARBs) have been shown to improve clinical outcomes. However, recent contrasting evidence regarding the dual RAAS blockade has also been presented. Very few studies have investigated the effectiveness of this dual blockade among Diabetic Nephropathy (DN) patients in association with albuminuria or proteinuria that is why we did this review. A review of Randomized Controlled Trial (RCT) studies (n=45) reporting on the dose-response analysis among DN patients using the RAAS blockade and other monotherapies over a 25-year period was performed. Overall, 45 studies of DN patients (n=18,628) with albuminuria or proteinuria were included. An association between dual RAAS blockade and DN has observed in which 18 of the 45 datasets revealed that combination therapies were effective among DN patients. Although there was a decline in albuminuria (mean difference: -19.93 mcg/L; 95% CI -50.32-10.47; I2=87.8%, p=0.000) and a slight decline in proteinuria (mean difference: -0.19 mg/mmol; 95% CI -2.32-2.70; I2=99.2%, p=0.000) with dual RAAS blockade combination therapy, these results demonstrated high heterogeneity among studies with non-significant effects. Based on this study, it appears that dual RAAS blockade (or a combination of therapies) is a neutral treatment for patients with DN presenting with symptoms of albuminuria and/or proteinuria. Therefore, other factors must be considered when recommending therapies for DN patients.
 

Bart A Van Wagensveld & Karla El Barmaki

Quro Obesity Center, UAE

Title: Obesity and weight management
Speaker
Biography:

Bart A Van Wagensveld has completed his MD in 1995 and PhD in 1998  from the University of Amsterdam, the Netherlands. He was a General Surgeon at the Academic Medical Center in Amsterdam, the Netherlands and specialized in Gastro-Intestinal and Laparoscopic surgery. 
 
Karla El Barmaki is a clinical dietitian who holds a Bachelor’s degree in Earth and Life Sciences (2007), a Bachelor’s degree in Nutrition and Dietetics (2009) and a Master’s degree in Sports Nutrition and Physiology (2013) from Saint Joseph University in Beirut, Lebanon. She completed an internship at a reputable hospital in Beirut, where she provided patients with individualized nutritional care tailored to their medical needs.  
 
 

Abstract:

According to WHO, obesity is defined as an abnormal or excessive fat accumulation that presents a risk to health. It is measured based on the BMI (BMI (kg/m2) =Weight (kg) ÷ Height (m2)) Based on the BMI value people are classified as underweight (<18.5), Normal (18.5-24.9), overweight (25-29.9), obesity (30-39.9) and morbid obesity (40+). The study shows that the main causes of obesity were peoples energy intake was high compared to expenditure which leads to increasing obesity levels. Worldwide obesity has more than tripled since 1975. In 2016, more than 1.9 billion (39%) adults (≥ 18 years) were overweight (39% of men and 40% of women). Of these, over 650 million (13%) were obese (11% of men and 15% of women). Most of the world’s population lives in countries where overweight and obesity kills more people than underweight. 41 million children under the age of 5 were overweight or obese in 2016. In order to reduce the rate of morbid obesity, bariatric surgery is the only effective treatment with long-lasting results. Bariatric surgery leads to a reduction in mortality rates after 5Y, which translates to a decrease in the relative risk of death by 89%. It is also known that obesity is a major risk factor for developing T2DM, with 86% of T2DM patients were either overweight or obese in the UK from this study. Thus, significantly higher diabetes remission rates were reported for gastric bypass (p<0.001) and biliopancreatic diversion (p<0.001) compared to medical therapy. 

Mohsina Hyder K

JSS Academy of Higher Education and Research, India

Title: Knowledge, attitude and practice among prediabetes participated in prediabetes education program
Speaker
Biography:

Mohsina Hyder K is currently pursuing Doctoral degree at JSS College of Pharmacy, Ooty under JSS Academy of Higher Education and Research, Mysuru. Her project study is on prediabetes.
 

Abstract:

Prevalence of prediabetes has been increasing globally and it is estimated that 470 million people would have prediabetes by 2030. Progression to T2DM happens swiftly attributed to dietary patterns and sedentary lifestyle. T2DM carries high morbidity and has a huge health and financial impact. The lack of knowledge among the prediabetics is the major factor contributing to failure in disease progression prevention. Recent studies highlight the importance of diabetes education programs. We aimed to organize Prediabetes Education Program (PEP) as 90% people with prediabetes are still unaware on it. Prediabetes Education Program is a cost effective strategy among health literacy for prevention and control of diabetes and its complications by preventing the prediabetes progression. This study involves construction and validation of KAP questionnaire for prediabetes. This is a self-administered 30 items questionnaire administered to prediabetes through medical screening camps conducted over selected districts of South India. The questionnaire development involved several steps like conceptualization, questionnaire design, literature review, experts review, pretest, pilot tests and also validation procedures like face validity, factor analysis, and Cronbach’s alpha. The validated questionnaire was administered to 210 prediabetics including males and females under the age group of 25 to 55 years who participated in PEP at baseline and final visit. Questionnaire showed satisfactory validity and reliability and fairly easy to read scores in readability tests. Outcomes were measured by comparing scores obtained before and after providing prediabetes education and counseling. Patient knowledge deficits were identified and proper counseling was provided. Significant improvements were observed with the KAP domains of prediabetes towards disease management.
 

Lailan Safina Nasution

University of Indonesia, Indonesia

Title: The adipocyte response to autophagy in adult rat groups receiving different nutritional treatments during childhood
Speaker
Biography:

Lailan Safi na Nasution is currently a Doctoral student in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia. She is also working as a Lecturer in the Department of Nutrition Faculty of Medicine, Universitas Muhammadiyah Jakarta, Indonesia.
 

Abstract:

Studies reported autophagy gene expressions are increased in the visceral fat in obese persons, associated with obesity related cardio-metabolic risk. It wasn’t known whether this up-regulation differs in obese persons who were already fat from childhood compared to people who were undernourished at a young age. MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3β) is known as an autophagy-regulating gene. We used rats, a common test subject in obesity experimentation. We hypothesize that autophagy gene expression is higher in the visceral adipocytes of obese adult rats which were undernourished at childhood in comparison to obese adult rats which were already obese before-hand. Four-week-old male Sprague-Dawley rats, after acclimatization, were randomly assigned to three treatment groups given a low-caloric diet (n=5), a standard-caloric diet (n=5) and a high-fat diet (n=5) for 8 weeks. Afterwards, all groups were fed a high-fat diet for 20 weeks. There was a group fed with standard chow diet as control. The visceral adipose fat was then collected for PCR examination. After the first standard chow diet as control 8 weeks, the group was given a low-caloric diet which had a significantly lower body weight than other groups. Aft er the following 20 weeks, this group experienced the highest change in body weight. The relative mRNA expression of the MAP1LC3B/LC3B of this group increased significantly compared to control (p=0.047) and the high fat diet group (p0.037). In conclusion we found that obese adult rats that were undernourished at childhood have a higher relative autophagy gene expression compared to those who were previously normal or obese.
 

  • Advanced Treatments for Diabetes | Biochemistry & Metabolism | Obesity Health Effects | Nutrition and Health | Diabetes Nutrition | Control of Obesity
Location: Carlton Palace Hotel, Dubai
Speaker

Chair

Moinuddin

Aligarh Muslim University, India

Speaker

Co-Chair

Dana Al-Hamwi

Dr. Dana Diet Center, UAE

Session Introduction

James Joseph

God's Own Food Solution Pvt Ltd., India

Title: New evidence to prove green jackfruit can reduce lifestyle diseases and demand for diabetic medication
Speaker
Biography:

James Joseph has completed his Masters in Engineering Business Management from University of Warwick, UK and has a Degree in Mechanical Engineering from the College of Engineering, Thiruvananthapuram.

Abstract:

For 60 years since its founding, Kerala took pride as the number one state in the country on life expectancy, receiving praise from world renowned global health expert, professor Hans Rosling. Prof Rosling puts Kerala ahead of Washington DC on Human Health Index at a fraction of per capita income. However, lifestyle diseases like diabetes is now in the order of an epidemic in the state reducing the life expectancy of our adult population above the age group of 30. For the first time Kerala lost out its number one position on life expectancy to Jammu and Kashmir due to an alarming drop in life expectancy after the age of 30 compared to J&K as per 2010-14 census data. Root cause of our problem with diabetes and lifestyle diseases is the rapid increase of starch in our diet over the past 60 years through rice, wheat, and tubers like cassava. Through years of policy interventions we were able to make starch more affordable but the overcorrection is now hurting our health than helping it. In order for Kerala to get back and retain our number one position in life expectancy, we have to cut back our starch consumption from half a plate to a quarter and increase consumption of our grossly underutilized green jackfruits. This talk will scientifically explain why one of Kerala’s oldest traditions of eating green jackfruit as a meal is the perfect plate for diabetes and lifestyle diseases. The results from the first glycemic research conducted on green jackfruit at Sydney University, first randomized control trial on green jackfruit meal showing reduction in HbA1c are as follows. 
1. Increased awareness from declaring Jackfruit as the Statefruit in March 2018 and the one meal campaign increased consumption of  green jackfruit meal during the season, April to June, with prices sky rocketing to Rs 20 ($ 0.3) per Kg for a fruit which was mostly wasted.
2. From April 2018 the record showed a decline in Anti-diabetes medicine sales in Kerala government pharmacies reaching a 25% drop in May and June compared to March.
3. Aft er the Jackfruit season got over in July, sales started steadily increasing every month and by October it returned back to March 2018 level.
4. A review of three year sales record also showed month to month and year to year decline of medicine sales during the jackfruit season in 2018, while there was a month to month and year to year increase in sales after the season.
 
Conclusions: The results clearly shows there is a definite relation between increased consumption of green jackfruit meal as an alternate to rice and reduced demand for diabetes medicine in Kerala during jackfruit season. And a rapid increase in Diabetes medicine sales when people switched back to rice after the season. This further shows the results already seen from the randomized control study on 36 patients can be reproduced on a larger population statewide. We now have a) internal product data to establish nutritional and glycemic advantage for green jackfruit, b) external interventional study on patients showing HbAa1c reduction with jackfruit meal and c) empirical evidence on reduction in demand for diabetes medication during jackfruit season. While Kerala is struggling to find a solution to contain its rapidly increasing health care costs and early deaths from lifestyle diseases like type 2 diabetes, this study shows there is a significant opportunity to conduct a multi-center clinical trial on green jackfruit meal as an alternate to rice and formulate policies to use its mostly wasted natural resource, green jackfruit as a medical nutrition therapy like the Mediterranean diet recommended by ADA.

Ajmila Islam

American University in Dubai, UAE

Title: Whole grains, fruits and vegetables: Do they help in weight management
Speaker
Biography:

Ajmila Islam is currently working as an Assistant Professor of Natural Sciences at the American University in Dubai. She has also worked in the area of Microbiology and Molecular Biology. She has published research works in colorectal cancer and obesity.
 

Abstract:

Whole grains, which are less-processed forms such as whole wheat, brown rice and oats digested more slowly than refined grains. It is speculated that they have a greater effect on maintaining proper balance in blood sugar and insulin levels, which may help keep hunger level low and creates satiety. This is also true for most vegetables and fruits, which contain high fiber. These low glycemic index foods have tremendous benefits for disease prevention, as well as there is also evidence that they can help prevent weight gain. The evidence for weight control is much stronger for whole grains than it is for fruits and vegetables. The most recent Harvard School of Public Health diet and lifestyle change study supports that people who increased their intake of whole grains, whole fruits (not fruit juice) and vegetables over the period of 20 years gained less weight. This study supports the fact that when people increase their intake of these foods, they cut back on calories from other foods. Fiber is one of the components that may be responsible for offering weight control benefits of these foods, since fiber slows digestion and helps in controlling hunger. On the other hand, fruits and vegetables are high in water, which may help people feel fuller on fewer calories.
 

Tigist W Leulseged

St. Paul Hospital Millennium Medical College, Ethiopia

Title: Time to optimal glycaemic control and prognostic factors among Type 2 diabetes mellitus patients in public teaching hospitals in Addis Ababa, Ethiopia
Speaker
Biography:

Tigist W. Leulseged is a medical doctor and public health specialist currently working as a lecture at Endocrinology unit under Department of Internal Medicine, St. Paul’s Hospital Millennium Medical College in Addis Ababa, Ethiopia. Her research interests are chronic illnesses particularly diabetes epidemiology including gestational diabetes, treatment, patient involvement in effective management and quality of services provided. She has experience in related research areas in both hospitals and teaching institutions.
 

Abstract:

Background: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. Poorly managed diabetes leads to serious complications and early death. The prevalence of diabetes has been increasing over the past few decades. Ethiopia is one of African countries with the highest number of people living with diabetes. Studies conducted in Ethiopia and other countries mainly focused on level of glycemic control at one point in time. Studies targeting the time that a patient stayed in a poor glycemic level are lacking.

Objective: To estimate time to fi rst optimal glycemic control and to identify prognostic factors among Type-2 Diabetes Mellitus (T2DM) patients in public teaching hospitals in Addis Ababa, Ethiopia.

Methods: A hospital based retrospective chart review study was conducted from April to July 2018 at diabetes clinic of Addis Ababa’s public teaching hospitals among randomly selected sample of 685 charts of T2DM patients who were on follow up from January 1, 2013 to June 30, 2017. Data was collected using pretested data abstraction tool. Data was checked, coded and entered to Epi-Info V.7.2.1.0 and exported to SPSS V.23.0 and STATA V.14.1 for analysis. Descriptive statistics is presented with frequency tables, KaplanMeier plots and median survival times. Association was done using Log-rank test and Cox proportional hazard survival model, where hazard ratio, P-value and 95% CI for hazard ratio were used for testing signifi cance and interpretation of results.

Results: Median time to fi rst optimal glycemic control among the study population was 9.5 months. Th e major factors that aff ect it are age group (HR=0.635, 95% CI: 0.486-0.831 for 50-59 years, HR=0.558, 95% CI: 0.403-0.771 for 60-69 years and HR=0.495, 95% CI: 0.310-0.790 for ≥70 years), diabetes neuropathy (HR=0.502, 95% CI: 0.375-0.672), more than one complication (HR=0.381, 95% CI: 0.177-0.816), hypertension (HR=0.611, 95% CI: 0.486-0.769), dyslipidemia (HR=0.609, 95% CI: 0.450-0.824), cardiovascular disease (HR=0.670, 95% CI: 0.458-0.979) and hospital patient treated at (HR=1.273, 95% CI: 1.052-1.541).

Conclusion: Median time to first optimal glycemic control among T2DM patients is longer than expected which might imply that patients are being exposed to more risk of complication and death.

Vani Pulijala

Astra Healthcare Private Limited, India

Title: Make tea as your new medicine to prevent the epidemic of lifestyle diseases
Speaker
Biography:

Vani Pulijala is the Founder of Astra Healthcare Private Limited. She has 15 years of experience in the healthcare industry. She has completed her MBBS from Kakatiya Medical College Warangal and her Post-graduation MD in Biochemistry from Gandhi Medical College, Hyderabad. She has completed Fellowship in Applied Nutrition and also a Certifi cate degree in Human Applied Nutrition from Cambridge, UK and is practicing as a Clinical Nutritionist. Her research interest studies is on the Indian spices on prevention and treatment of metabolic diseases, teach the rural India about the importance of perfect and balanced nutrition to prevent malnutrition in rural and tribal areas of India.
 

Abstract:

Chronic diseases are a major burden, creating a global warning in today’s world. Our aim was to study the role and effectiveness of tea (Camellia sinensis) in preventing the burden of chronic diseases, like diabetes, hypertension, thyroid, cancer, PCOS, osteoarthritis, etc. There are a many studies and publications, supporting the statement that tea has a potential effect in reducing the burden of chronic diseases. Only confusion that is bothering the public all around the world, is actually regarding the exact amount of intake of tea and the variants of tea which should be taken on a daily basis to attain all the hidden healthy benefits of the second most commonly consumed drink in the world, which is tea. This presentation was taken up to reveal the clear picture of such queries. There was a positive correlation between the regular intake of minimum 4 cups of tea daily and reduction in the incidence of chronic diseases. Black tea, green tea, white tea, oolong tea are few of the variants of tea which has tremendous benefits in regulating the metabolism of our body, thus preventing the metabolic disease burden all around the world.